Site Links
Windows 2008

Site links can be configured as IP site links or SMTP site links. When would you used SMTP?
SMTP stands for Simple Mail Transport Protocol and has nothing to do with mail but the protocol is much more forgiven so you would used this when the WAN link is very slow and unreliable. Then you would configure a SMTP site link.

Also the traffic would be in clear text so you want to use certificates to authenticate the connection. With IP site links the traffic would be over RPC and it would be using Kerberos so that's secure.
Windows 2008

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